Lilith was a powerful white-eyed demon and the first demon Lucifer created, as well as being the final seal of the 66 Seals that had to be broken for him to be freed from his cage. She was trapped in Hell until May 2007, when she escaped and effortlessly defeated multiple rival demons to take over the deceased Azazel's former position as leader of the army of demons that he had unleashed alongside her. Lilith led this army on Earth and commanded the rest of the forces of Hell in the War of the Seals against the Host of Heaven. She was responsible for the destruction of sixty-six seals guarding Lucifer's cage in 2008, ending with her allowing Sam Winchester to kill her and freeing Lucifer in 2009.
Although the Winchesters wanted to stop Lilith from raising Lucifer, their grudge with her ran far deeper than this, due to that she unleashed a hellhound upon a helpless Dean, killing him, to send him to Hell, and forcing an equally helpless Sam to watch it all happen in front of him.
Powers and Stats
Tier: Likely 7-B
Name: Lilith, The First Demon, The Final Seal, Queen of Hell
Age: Hundreds of Thousands of Years
Classification: White-Eyed Demon, First Demon, Human (Formerly)
Powers and Abilities: Superhuman Physical Characteristics, Telekinesis, Teleportation, Telepathy, Pyrokinesis, Photokinesis, Regeneration (Mid-Low), Possession, Soul Manipulation, Immortality (Types 1 and 3), Supernatural Perception, Reality Warping (Through Deals), Higher Resistance to Demon-Killing Blades, Angel Blades and Holy Water
Speed: Subsonic+ with Supersonic Reactions, Possibly much higher
Lifting Strength: Class 5
Striking Strength: Room Class
Durability: At least Building level+, possibly City level in Host (Her true nature as a non-corporeal spirit makes her very hard to kill
Range: At least several meters for Attacks, possibly Planetary for certain abilitites
Standard Equipment: None notable
Intelligence: Quite High. The first demon, has lived for hundreds of thousands of years.
Weaknesses: Devil's Trap, Hex Bags, Special Children