The Despair of the Endless that first appears in comics is actually the second Despair, and due to the fact that she seems to assume the same status as her predecessor, our first impression of her can lead to the belief that she is the original Despair, which would be incorrect. She is still Desire's twin (even though she came after Desire) and from what can be seen, other then a few small details appearance-wise, she isn't much different from the original Despair.
However, based off of what has been seen, she seems a lot less independent and more "despairing" then the original. For one thing, almost all of her appearances she is alongside Desire or being "manipulated" by Desire, although Desire often appears on his/her own. When we do see Despair in solitude, she is in The Gray Realm, a realm of fog and mirrors, or windows, windows into the souls of those who feel despair. Of course, Despair seems to be more depressed then even her people and has been known to mutilate herself.
In regards to relationships with her siblings, other than Desire, Despair also seems to have a love for Destruction, and perhaps it was his leaving that helped drive her farther into the darkness of despair. She is usually silent though and doesn't seem to be much of a "people-person" and her mannerisms and voice can at times scare Delirium, though it doesn't seem like Despair wants to intentionally frighten her sister. In fact Despair seems like a gentle, quiet woman and based upon her attitudes it brings up the question if she became Despair unwillingly?
Powers and Stats
Tier: High 1-B
Name: Despair of the Endless, Aponia
Origin: DC Comics/Vertigo
Gender: Inapplicable. Appears as Female
Age: As Old as the concept of Despair
Classification: Endless, Embodiment of Despair
Powers and Abilities: Superhuman Physical Characteristics, Immortality (Types 1, 3 and 4), Regeneration (Mid-Godly or High-Godly), Reality Warping, Time Manipulation, Spatial Manipulation, Mind Manipulation, Soul Manipulation, Empathic Manipulation, Acausality, Causality Manipulation, Control over Despair, Holy Manipulation, Shapeshifting, Telepathy, Teleportation, Flight, Magic, Nigh-Omnipresence
Attack Potency: High Hyperverse level (All members of the Endless are the primal truths which compose every aspect of The Presence's infinitely layered creation, and have been described as Wave Functions.)
Lifting Strength: Immeasurable
Striking Strength: High Hyperversal
Range: Irrelevant (Can reach into the void outside Creation)
Standard Equipment: None notable
Weaknesses: Is bound by complex customs and traditions, cannot spill the blood of a family member.
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