In the year 1711, a group of alchemists are granted an elixir of immortality, with the stipulation that they must kill each other until there can be only one. The now-immortal group unanimously decides it wasn't worth it and destroy the elixir; but one of them, Slizard Quates, starts to kill off his fellow immortals. To reduce the risk of Quates tracking them all down, the group separates and goes their separate ways. Neither of them crosses paths again till 1930, Manhattan, when Quates manages to create a new elixir of immortality. However, he loses it and it ends up going around town, taken to be a bottle of alcohol and unknowingly drunk by many residents. The drinkers of this new elixir include Isaac and Miria, an eccentric pair of thieves; the Gandor brothers, a Mafia family; and their associates in the Camorra, the Martillos (who employ some of the original immortals). Now, not only are a new group of immortals created, but the simmering criminal underworld is about to explode.
Power of the Verse
The verse isn't actually very strong, possessing mostly street level threats with a few Room/Small Building level hard-hitters, but this doesn't diminish the excellent quality of the series at all. However, while this verse is not especially strong, it does contain several immortal regenerators, shapeshifters, alchemists and an effectively omnipresent reality-warping wish-granting demon. However, the verse's two top tiers, Ronny Schiatto and Claire Stanfield, are so hilariously far above the other characters in performance that it's effectively impossible to determine just how powerful they actually are, since they never have to put any effort into defeating anyone.